Nov 21, 2025
3 min read
A new study found that rejection increased two-fold, revealing the reason for rejection at the mRNA level
Scientists are the first to reject half-tooth transplants
The reexamination was repeated twice for two transfers, which revealed the reasons for rejection of the transfer at the cell level
Faced with a shortage of organs needed by tens of thousands of patients, scientists are studying pig organs as a potential solution.With appropriate genetic modification for humans and transplantation in the same way as human organs, it is hoped that they will perform as well as organs transplanted from human donors.But the human body still rejects them.
A new study published in November in the journal Nature offers new hope.In it, a group of national doctors and how they stopped the human body from leaving the pig part not once, but twice.
Fun fact: Liver and kidney are just the beginning
Concerning the organs of the renal and renal cavities is first.From the human eye, the valve and the knee can be transferred between people. Azuru is a kidney, a brain that has died because it died.After 61 days of testing, the patient's body failed twice.
"It's a big step forward," Robert Montgomery, the study's lead author and director of the NYU Langone Transplant Institute, where the study was conducted, told ABC News' Mary Kekatos."As we move forward, I believe that within the next few years we will be in a situation where gene-edited pig organs will be an alternative to human organs."
Muhamad Mohiuddin said: "In my opinion, this is the first evidence of the first human rejection of pigs in 2022 and he was not involved in this study, he told Rachel of Nature.
The team was able to so successfully understand and reverse the rejections thanks to the daily examination of the patient, monitoring the functioning of his organs at the cellular level.This tracking allowed researchers to detect the rejection of both organs five days earlier than otherwise, ABC reported.
"We can find the point that is the most biological world by doing samples in blood, tap water and creating things to approach" and that is what is special about this study. I think he is probably the most educated person in history."
Researchers analyzed patients' blood to identify the specific cells and antibodies that caused rejection.They found that the pig organs expressed higher levels of genes that the human immune system interprets as foreign, triggering an immune response.Montgomery told Nature that T cells - white blood cells that respond to bacteria and unknown invaders - also play a greater role in rejection than previously thought.
After the 61-day mark, the study marked the longest period in which a brain-dead patient survived, and hopes to use this technique in the future, says CNN's Jen Christensen.
"Sixty-one days of stable kidney function is a new proof of concept, and it confirms that genetically engineered pig kidneys can maintain physiological function in the human circulation," Sarwal said.
Such success may decide to wait for patients in need, the researchers hope.Currently, more than 18,000 people in the United States are waiting for an organ transplant, according to the United Organ Exchange Network.Less than half that number received a transplant in 2024.
Montgomery's team is now testing the immunosuppression techniques of the pig transplants in 20 additional patients, Montgomery tells CNN, so these findings can be replicated in more than one patient.
Despite the challenge posed by the body's immune response to pig organs, the researchers concluded that "at least the engineered pig kidney can support long-term physiological functions in humans."
Knowing that "will give us a sense of relief going into clinical trials ... knowing that when you make a pig a human a human," Montgom told CNN.
