Does the Covid-19 vaccine also help fight cancer?

There is some scientific literature that supports the idea that the so-called 'Angela' vaccine program can help cancer patients.

Could mRNA vaccines hold the key to stopping cancer development? A Northeastern University vaccine expert talks about recent progress.

There is scientific literature supporting the idea that so-called messenger RNA vaccines, which trigger a robust immune response within the body, can help cancer patients.

The COVID-19 vaccines could do much more than just ward off viral infections: They could teach our immune systems how to fight cancer more effectively.

There is a growing body of scientific literature that supports the idea that Messenger RNA (MRNA) can help cancer patients by invoking an immune response in the body.

“There is enough evidence to show how you can make a difference in the fact that it also prevents disease, including from universities that are starting to see it in patients with cancer,” says Anijar Amiji, seeing this in universities that are starting to see it in patients in the sciences and electronics fields.

Amiji and his colleagues are working on a menacna delivery system.As part of that work, he focused not only on how to make the vaccine ready and more effective, but also on changing the deep structure without freezing it.

Unlike traditional vaccines, which use weakened or inactivated viruses, mRNA vaccines work by giving the body genetic instructions to make a small component of a specific protein, then training the immune system to recognize and attack the right pathogens — or, in the case of cancer vaccines, diseased cells — when they appear.

The Public Directory is the main of Morna Woods in charge of the Canks on the Directory.

Some cancer-specific vaccines, such as the human papillomavirus (HPV) and hepatitis B vaccines, have already proven effective. There are also therapeutic vaccines that aim to treat existing cancer by training the immune system to recognize and attack tumor-specific proteins.

Preventive vaccines are already widely used, but most therapeutic cancer vaccines, including mRNA-based vaccines, are still in clinical trials.

But a previous study published last week in Nature shows just how versatile mRNA vaccines can be, finding that cancer patients who received a COVID-19 mRNA vaccine lived significantly longer when receiving immunotherapy than their unvaccinated counterparts.

Researchers analyzed data from more than 1,000 patients with lung cancer and small cell carcinoma.The researchers divided them into two groups: those who received the MRNA COVID-19 vaccine, those who received the vaccine within 37.3 months, those who received the vaccine within 37.3 months, and those who received the vaccine within 37.3 months were seen in patients who were vaccinated.

The investigators also concluded in a separate analysis that given mRNA vaccination and immunotherapy reduced the growth of mice.

"This is specific to mRNA vaccines, so mRNA vaccines from Modernia or Pfizer would make a big difference in either cancer patients," says Amidji.

Brandon Dionne, clinical associate professor of pharmacology and health systems sciences, said the findings are "not entirely surprising," based on other in vitro data and animal studies that suggest mRNA vaccines "prime the immune system" and generate a "nonspecific response" that can help the body fight other diseases.

COVID vaccines work in this cancer because they work in conjunction with immune checkpoint inhibitors, which are drugs that prevent tumors from opening checkpoints that suppress the immune response to cancer cells.

“This combination prevents the cells from blocking the immune response and then also stimulates a stronger immune response that then begins to attack the cancer cells,” says Dionne.

Dionne noted that the first clinical trial involving an mRNA vaccine was for the treatment of prostate cancer.

Experts say that the drug sector is to give examples of drugs with beneficial effects, one famous example is drug-1 drug, such as OzembIC and Wegovi.Originally designed to control blood sugar in diabetics, they are now widely used as a heroin drug.

Thus, the drugs now used to treat erectile dysfunction began as drugs to treat pulmonary hypertension, says Dionne.Other drugs, such as the antibiotic azithromycin, have not shown specific therapeutic effects beyond their original use.

"To properly sensitize your immune system to attack tumors, you have to prime it," says Amidji."And right now with certain cancers, especially lung cancer and melanoma, those tumors are what we call 'cold' tumors, meaning they don't allow our immune cells to infiltrate and do their job."

Researchers have found that miRNA vaccines can help turn these cold tumors into "warm" tumors, signaling the immune system to respond more effectively. The effect appears to be strongest in patients who have been vaccinated before or who received miRNA injections when starting treatment, Ameji said.

"Hot" tumors are full of active cancer fighting, making them more amenable to immunosuppressive therapy.On the other hand, apples are very weak cells of the body or around them, they have a purpose of protection of the body which is difficult for cancer cells.Because the immune system is not produced in these parts, the bones are difficult to attack with treatments such as preventive measures.

Researchers are now investigating whether vaccines can help "wake up" cold tumors and improve immune responses, an issue Amiji says needs further study.

"Imagine if we retrospectively analyzed the data to compare vaccinated and unvaccinated patients—would we be able to determine whether the COVID vaccine was effective in preventing cancer in the first place?"Amiji says."We would obviously need to do this study with a larger cohort, but it would be a great discovery."