The modified killer cells kill cancer cells very effectively – a healing practice

Reprogramming immune cells as an effective cancer killer

A Canadian research team has shown that modified immune cells that kill cancerous tumors can be used as a treatment for people with late-stage cancer. The altered metabolism enables the killer cells of the immune system to survive better inside the tumor tissues and thus kill the cancer cells more effectively.

Researchers led by Professor Ali Ashkar and Sophie Poznansky from McMaster University in Canada have discovered that trained immune cells are highly effective in killing cancer cells. A change in the metabolism of natural killer (NK) cells enabled immune cells to overcome defenses within tumors. In this way, they were able to destroy cancer cells from advanced ovarian and lung tumors. The results were recently published in the popular magazine.Cell metabolism” Foot.

A hurdle in cancer immunotherapy

In the past decade, cancer immunotherapy has had enormous curative effects in people with leukemia. However, the immunosuppressive conditions within solid tumors, whose violent growth leads to starvation of surrounding healthy tissues, has been a formidable obstacle to immune cell therapies.

Surrounding tumors suppress immune cells

Lead author Poznanski explains in a press release about the study findings.

“With this understanding, we were able to reverse the dysfunction in the natural killer cells by reconfiguring the current metabolic drug that reproduced them from energy,” Poznansky added.

Metabolism mimics cancer cells

The research work also clarified the decades-old question of how cancer cells can suppress natural killer cells. According to the slogan, “To defeat your enemy, you have to think like your enemy,” researchers have reprogrammed the metabolism of killer cells in a way that mimics the metabolism of cancer cells. Then the modified natural killer cells were better able to adapt to the tumor environment.

Defeat the enemy with their weapons

“We just hoped that the modified NK cells would be more resistant to tumor suppression,” says Professor Ashkar. Working group expectations were exceeded: After reprogramming, immune cells function better inside tumors than outside. They have exploited the anti-tumor environment to their advantage.

“This is the first report of an immune anti-tumor cell that uses anti-tumor resistance to its advantage,” Ashkar said. This discovery could represent a paradigm shift in cancer immunotherapy.

To date, only natural killer cell immunotherapy has been used for leukemia

So far, natural killer cells have proven themselves only against leukemia. The professor stresses that “reprogrammed and re-trained natural killer cells may mean that people with incurable cancer have a safe and effective treatment option.” Survival rates from lung and ovarian cancer have remained low over the past 30 years. This can change with new knowledge.

Hardly any side effects are known

Additionally, the researchers indicate that NK cell immunotherapy has so far been proven safe. Few side effects are known. Most patients have no side effects whatsoever.

“This could have real potential for treating ovarian cancer, lung cancer and other poorly diagnosed tumors,” adds Hal Herty, professor of oncology from the study team. Ovarian cancer, in particular, is one of the most immunosuppressive tumors, and a major reason why survival rates have not improved.

Big breakthrough?

The therapeutic effects observed in preclinical models in this study represent a major advance, according to Hurt. “The next step is to translate this promising treatment into clinical trials in patients, and we plan to start trials soon to demonstrate this approach in patients for testing with recurrent ovarian cancer,” Professor Hertie sums up. (Fb)