Diabetes: New research advances thanks to study of satiety mechanism | press room

Brain entry of leptin by LepR tanycytic: the EGFR shuttle controls lipid metabolism and pancreatic function.

Manon Duquen¹, Cynthia Fulgiera^2#Cyril Boruh^{3 #}Marion Millet^{4, #}Anisia Silva^{5 #}, Jerome Clasadounte^1#, Monica Empernon¹Daniela Fernando¹Coral, Ines Martinez¹Sumaya Kusumakshi⁶, Emily Caron¹, S. Rasika¹, Eleonora Delliglia¹Natalie Joy^1,12Astoro Oishi⁵Massimiliano Mazzoni⁷Eric Trinke⁸Jean Tavernier,⁹Young Bum Kim¹¹Stefan Uri⁴Ralph Jokers⁵Marcus Schwanninger¹⁰Ulrich Bohm⁶Robin Nogueras²Jean-Sebastian Anicott³Stefan Gazmann^{4 &}Julie Dam^{5 &}Vincent Prevot^{1 & *}

¹ University. Lille, Inserm, CHU Lille, Laboratory of Neuroendocrine Development and Plasticity, Lille Neuroscience & Cognition, UMR-S1172, EGID, DISTALZ, F-59000 Lille, France

² Simos, University of Santiago de Compostela, Institute of Health Research, Santiago de Compostela, 15782, Spain – CIBER Pathophysiology of Obesity and Nutrition (CIBERobn), 15706, Spain

³ University. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, CNRS, U1283 – UMR 8199 – EGID, F-59000 Lille, France

⁴ National Center for Scientific Research, University of Strasbourg, Institute of Cellular and Integrative Neurosciences, F-67000 Strasbourg, France.

⁵ Cochin Institute, Inserm U1016, CNRS UMR 8104, University Paris Descartes, Sorbonne Paris City, Paris, France

⁶ Experimental Pharmacology, Center for Molecular Signaling (PZMS), Saarland University Medical School, 66421, Homburg, Germany

⁷ Laboratory of Oncology and Angiogenesis, Center for Cancer Biology, VIB, Department of Oncology, KU Leuven, Leuven, B3000, Belgium

⁸ Cisbio Bioassays, Marcel Boiteux Technological Park, BP84175, F-30200 Codolet, France

⁹ VIB-UGent Center for Medical Biotechnology, Ghent, Belgium.

¹⁰ Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany

¹¹ Department of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.

¹² Flow core facility, BioImaging Center of Lille, HU Campus, UMS2014-US41, F-59000 Lille, France

^# These authors contributed equally

^& These authors jointly supervised this work

nature metabolismAnd 2021

https://doi.org/10.1038/s42255-021-00432-5