Diabetes: New research advances thanks to study of satiety mechanism |  press room

Brain entry of leptin by LepR tanycytic: the EGFR shuttle controls lipid metabolism and pancreatic function.

Manon Duquen1, Cynthia Fulgiera2#Cyril Boruh3 #Marion Millet4, #Anisia Silva5 #, Jerome Clasadounte1#, Monica Empernon1Daniela Fernando1Coral, Ines Martinez1Sumaya Kusumakshi6, Emily Caron1, S. Rasika1, Eleonora Delliglia1Natalie Joy1,12Astoro Oishi5Massimiliano Mazzoni7Eric Trinke8Jean Tavernier,9Young Bum Kim11Stefan Uri4Ralph Jokers5Marcus Schwanninger10Ulrich Bohm6Robin Nogueras2Jean-Sebastian Anicott3Stefan Gazmann4 &Julie Dam5 &Vincent Prevot1 & *

1 University. Lille, Inserm, CHU Lille, Laboratory of Neuroendocrine Development and Plasticity, Lille Neuroscience & Cognition, UMR-S1172, EGID, DISTALZ, F-59000 Lille, France

2 Simos, University of Santiago de Compostela, Institute of Health Research, Santiago de Compostela, 15782, Spain – CIBER Pathophysiology of Obesity and Nutrition (CIBERobn), 15706, Spain

3 University. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, CNRS, U1283 – UMR 8199 – EGID, F-59000 Lille, France

4 National Center for Scientific Research, University of Strasbourg, Institute of Cellular and Integrative Neurosciences, F-67000 Strasbourg, France.

5 Cochin Institute, Inserm U1016, CNRS UMR 8104, University Paris Descartes, Sorbonne Paris City, Paris, France

6 Experimental Pharmacology, Center for Molecular Signaling (PZMS), Saarland University Medical School, 66421, Homburg, Germany

7 Laboratory of Oncology and Angiogenesis, Center for Cancer Biology, VIB, Department of Oncology, KU Leuven, Leuven, B3000, Belgium

8 Cisbio Bioassays, Marcel Boiteux Technological Park, BP84175, F-30200 Codolet, France

9 VIB-UGent Center for Medical Biotechnology, Ghent, Belgium.

10 Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany

11 Department of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.

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12 Flow core facility, BioImaging Center of Lille, HU Campus, UMS2014-US41, F-59000 Lille, France

# These authors contributed equally

& These authors jointly supervised this work

nature metabolismAnd 2021

https://doi.org/10.1038/s42255-021-00432-5

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