The DGN now emphasizes that anyone who has ever had chickenpox can in principle develop shingles. In the large retrospective cohort study conducted by the University of California, San Francisco, published on November 16, health data from the US OLDW database (“Optum Labs Data Warehouse”) of 2,039,854 people vaccinated against SARS-CoV-2 ( BioNTech/Pfizer, Moderna or Johnson-Johnson, for the period 12/2020 – 6/2021). The mean age of those vaccinated was 43.2 ± 16.3 years, 50.6% were female. Finally, from the entire cohort, 1,451 subjects with a diagnosis of shingles were screened for the frequency of a diagnosis of shingles in the ‘risk period’ (30 days after the first or second vaccination dose). The outcome was compared to later periods (‘control period’ 30–60 days post-vaccination). “As a result, coronavirus vaccination was not associated with an increased risk of VZV reactivation (IRR 0.91; p = 0.08),” explains DGN. And this, although according to the study authors, there is definitely one Reasonable mechanism mRNA-based COVID-19 vaccines can lead to herpes zoster infection. Accordingly, mRNA-inducible vaccines Toll-like receptor signaling pathwaywhich are involved in the latency and reactivation of varicella zoster virus.