A more detailed measure of the effectiveness of an anti-Covid vaccine?

In a preliminary study carried by the journal natureScientists claim to have demonstrated a precise link between the immune response and infection risk.

How does a person predict the protection provided by a dose of an anti-Covid vaccine? Aside from running long and tedious clinical trials, is there a way to know if the immune response provided by a vaccine is sufficiently protective? So many questions that the preliminary study provides some answers to, Regarding the review nature :

Oxford University Team, UK [partenaire du laboratoire AstraZeneca], showed a “protection link” from the trial participants’ immune responses – the first that a Covid-19 vaccine developer discovered. “

Protection is related to the precise immune response that provides protection against disease.

Neutralizing antibodies, a key indicator

The results of the preliminary study – because they were not validated by other scientists – Broadcast on medRxiv June 24. Previous studies had indicated that neutralizing antibodies, which prevent the virus from entering target cells, are a good indicator of the effectiveness of vaccines against Covid-19.

For example, vaccines from Pfizer and Moderna, which work very well, produce high levels of neutralizing antibodies, while these levels are lower with AstraZeneca or Johnson vaccines. & Johnson.

First work that cannot be extrapolated to other vaccines

The team compared the immune responses of 171 vaccinated with a harmless chimpanzee adenovirus who showed symptoms of Covid-19 with the response of 1404 vaccinated and had no symptoms of infection. In doing so, they have determined neutralizing antibody levels corresponding to the risk of infection, by adjusting their model according to the risk of exposure to the virus.

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Philip Dormitzer, Vice President and Chief Scientist for Viral Vaccines at Pfizer nature It is important to distinguish biomarkers that predict vaccine success from those that are actually responsible for protective effects. In addition, University College London vaccinologist David Goldblatt, who was not involved in the study, also has reservations about the possibility of extrapolating these results to other vaccines, particularly those using other technologies.

Source

Since 1869, this prestigious scientific journal – after several months of verification – has received reports on major innovations in all fields: from biology to physics, including astronomy. his age

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