Contract announced for nerve agent countermeasures

Aeolus Pharmaceuticals, a biotechnology company, announced on Monday that the National Institutes of Health CounterACT program has awarded a $736,951 contract to a University of Colorado scientist to develop medical countermeasures against nerve agents.
Manisha Patel, who works at the school's Anschutz Medical Campus, will develop AEOL 10150 under the contract ,titled "Evaluation of Neuroprotective Effects of AEOL 10150 against Chemical Threat Agents." The primary objective of the grant is to evaluate the neuroprotective efficacy of AEOL 10150 against pilocarpine-induced toxicity in rats.
Exposure to nerve agents, high levels of sulfur mustard or metabolic poisons can trigger seizures and a loss of consciousness. The two year award builds on Patel's research in rodent models of neurotoxicity and neurodegeneration. Her laboratory has demonstrated that oxidative stress plays a central role in seizure-induced brain injury and it is important to determine if AEOL 10150 is neuroprotective against nerve agents causing such injury.
"We are pleased to see the expansion of the research and development of AEOL 10150 as a broad spectrum medical countermeasure, and are grateful for the support that NIH CounterACT provides for the development of this promising compound," John L. McManus, the president and chief executive officer of Aeolus Pharmaceuticals, Inc., said. "With this project, the U.S. government is now funding research and testing of AEOL 10150 in five MCM indications. Aeolus appreciates our partnership with the University of Colorado and the excellent research that Dr. Patel has done to be awarded this grant, and looks forward to the results of her research."
The studies will build on prior work showing that AEOL 10150 is an effective countermeasure to protect the lungs from damage due to inhalation of sulfur mustard gas and chlorine gas. The countermeasure is currently under development as a broad spectrum medical countermeasure with support from the U.S. government.

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