How do glucocorticoids affect the brain?
so people glucocorticoids (such as cortisone), this can lead to changes in structure And the size from the brain. In addition, affected people also frequently experience symptoms of depression and fatigue.
In a new study conducted by experts from Leiden University Medical Center In the Netherlands, it was examined whether the administration of systemic and inhaled glucocorticoids was associated with changes in the volume of Gray matter or unclear The microstructure of white matter connected to the brain. The results were published in the journalBMJ is openPosted.
The data analyzed was from the UK Biobank
As part of the current research work, data from UK Biobank The assessment, which came from people between the ages of 40 and 69, was done. The UK Biobank is a prospective, population-based cohort study of recruited adults in the United Kingdom between 2006 and 2010.
The current study excluded subjects with a history of neurological, psychiatric, or endocrine disorders, or who reported a history of psychotropic use.
In general, the current study included 222 peopleWhich systemic glucocorticoids to use, 557 people with Application of inhaled glucocorticoids and 24,106 participants as a control group, the team reported.
Changes were examined using MRI scans of the brain
through the use of MRI brain scans Among the participants who received systemic or inhaled steroids and the subsequent comparison to people from the control group, the team attempted to changes in the brain To determine.
In addition, so-called linear regression analyzes were used to remove potential confounding factors from the data. Secondary findings of the investigation dealt with, among other things, Cognitive functions From the participants in addition to the performance emotional symptomsAccording to the researchers.
double white matter
The study showed that both systemic and inhaled glucocorticoid intake with a Decreased integrity of white matter Compared to people in the control group, the team reported. The effect is one systematic application was stronger.
In other words, if participants received glucocorticoids systemically (by tablets or injections) or inhaled them, this was the case. The least healthy white matter in the brain Compared to people in the control group who did not use any glucocorticoids.
Effects on the gray matter of the brain
It was also shown that systemic intake with a Larger volume of gray matter in the tail and application of inhalation with a Decreased gray matter volume in the amygdala Compared to the control group, the researchers explained.
The caudate and amygdala are structures of gray matter in the brain involved in cognitive and emotional processing.
Symptoms of depression and fatigue caused by glucocorticoids
In further evaluations, it became clear that systemic application of glucocorticoids also had worse results Cognitive tests It is connected.
Additionally, these individuals reported more symptoms of depression, lack of interest, stress/insomnia, and fatigue/lethargy than the control group, according to the research team. However, only participants who inhaled the glucocorticoid were affected by more fatigue/lethargy.
Glucocorticoids alter the brain
In conclusion, both systemic and inhaled glucocorticoid use are associated with decreased white matter integrity and limited changes in gray matter volume, according to the team’s report.
According to the researchers, this connection could be Neuropsychiatric side effects of diabetes medications That especially happens with long-term use. (as such)
Author and source information
This text complies with the requirements of specialized medical literature, medical guidelines, and current studies and has been verified by medical professionals.
- Merel van der Meulen, Jorge Miguel Amaya, Olaf M. Dekkers, Onno C. Meijer: Association between use of systemic and inhaled glucocorticoids and changes in brain volume and white matter microstructure: a cross-sectional study using data from the UK Biobank; At: BMJ Open (veröffentlicht 30.08.2022), BMJ is open
This article contains general advice only and should not be used for self-diagnosis or treatment. It cannot replace a visit to the doctor.