Heat stabilizers can inactivate pathogens, study says
With heat stabilization, the pathogens -- including viruses and bacteria -- were made invalid in terms of infection, but this method leaves important biological information intact. The research team used the Stabilizor system from Denator AB. Contagious pathogens are limited to being studied in lab facilities with biosafety levels of three or four (BSL-3 and BSL-4), although many of these facilities are missing the equipment necessary for the biological marking process. Thus, they are required to be inactivated before analysis can be completed.
According to the research team, systems like these could potentially speed up the development and testing process of vaccine and treatment candidates for multiple pathogens.
“We are very pleased with the initial results obtained with the heat stabilization technology," USAMRIID research scientist Lisa Cazares said. "We are constantly facing challenges when working with highly pathogenic agents and especially when downstream analysis requires removal of samples from containment such as protein biomarker discovery studies or drug efficacy analysis. Heat stabilization is unquestionably a promising tool for future use in BSL-3 and BSL-4 labs to enable proteomic analyses of infectious tissue samples."