Oral bacteria associated with primary rheumatoid arthritis
The bacterial makeup in the mouth clearly provides clues as to whether a person is at risk of developing rheumatoid arthritis, a research team from the Netherlands has shown. The oral bacteria from the at-risk groups were similar to the oral flora of people with early rheumatoid arthritis and were different from the bacteria circulating in healthy individuals.
Researchers from Amsterdam found similarities in the oral bacterial makeup of people with early rheumatoid arthritis and those at high risk of developing the disease compared to healthy people who were not at risk. The results indicate that oral flora plays a greater role in disease progression than previously thought. The study was recently published in the journal.Arthritis and Rheumatism“Was released.
The triggers for rheumatoid arthritis are unknown
Rheumatoid arthritis, too Chronic arthritis Called, it is the most common arthritis disease in Germany. Around one in 100 adults in this country suffers from this type of rheumatism. The causes and causes of rheumatoid arthritis are still not sufficiently understood. In addition to genetic factors, viruses and bacteria are also suspected to be the causative agents. The working group from Amsterdam is now providing new evidence of the bacterial origin of the disease.
Comparison of oral bacteria
The team compared the oral bacteria from three groups of 50 people each. The participants in the first group had the onset of arthritis, and the people in the second group had high risk factors for developing rheumatoid arthritis, but had no symptoms of the disease. The third group was a control group with healthy participants with no risk factors.
Inflammatory bacteria in the mouth
People at risk of developing rheumatoid arthritis and those who had already had the onset of the disease were more likely to have inflammatory bacteria in their mouths than healthy people. These Gram-negative bacteria were predominantly of the genus Prevotella and Veillonella.
Prevotella bacteria are usually part of the vaginal and gastrointestinal microbiome, but they may also be a potential source of infection. Bacteria of the genus Veillonella belong to the common oral microbiome, but under certain conditions they can also become pathogenic to humans, that is, pathogenic.
Does rheumatoid arthritis start in the lining of the mouth?
“Prevotella and Veillonella were found to have a higher relative frequency in saliva, and Veillonella were also found to have a higher relative frequency in tongue coating, both in patients with early rheumatoid arthritis and in people at risk compared to healthy controls,” total working group above. The study provides new evidence for the thesis that rheumatoid arthritis can arise in the oral mucosa. (Fb)
Author and source information
This text complies with the requirements of the specialized medical literature, medical guidelines and current studies and has been examined by medical professionals.
Diploma Editor (FH) Volker Plasik
- Johanna M Cross, Bernd W. Brandt, Mark J. Buijs, et al .: The oral microbiome in early rheumatoid arthritis patients and at-risk individuals differs from healthy controls; In: Arthritis and Rheumatism, 2021, newsroom.wiley.com
- German Rheumatology Association: Rheumatoid Arthritis (Accessed: 05/05/2021), rheuma-liga.de
This article is for general guidance only and is not intended to be used for self-diagnosis or self-medication. He cannot replace a visit to the doctor.