In short, this research explores the brain’s ability to cause disease on its own and “on its own,” and then be able to eliminate it.

studying In a few steps:

  1. Scientists induce colitis in mice.
  2. During colitis, several areas of the brain show increased neural activity, including the insula, a small area of ​​the brain responsible for internal perception – the body’s ability to estimate its physiological state through various metrics including hunger, thirst, pain, and heart rate, in particular. ;
  3. Scientists then hypothesize that if an inflammatory signal in an area of ​​the body can be ‘stored’ somewhere in the brain, particularly in the islet region, then this region responsible for endogenous sense could be involved in the disease;
  4. Genetic manipulation techniques allow scientists to “capture” (or target) groups of neurons in the insular cortex that show this increased activity during inflammation;
  5. Once the mice were healthy, the researchers artificially firing these neurons again and without using any other stimulus, they found that inflammation reappeared, in the same area where it was before.

It is enough for the brain to “remember” the inflammation to reactivate it.

If the brain is able to generate disease, is it also possible to stop it?

The opposite effect is always seen in mice: In mice that show active inflammation, suppression of neurons that “remember” leads to an immediate reduction in inflammation.

There are still many challenges to overcome to validate this concept in humans, but it appears to reduce the memory footprint (in the brain) of certain chronic inflammatory conditions such as Crohn’s disease, psoriasis, and other autoimmune diseases. It constitutes a completely new therapeutic avenue.

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The link between insula disease and intuition is likely to be progressive and a survival advantage The immune system can be activated by memory alone without the need for any other external stimulus. The body must respond to the infection as quickly as possible before the attacking bacteria or viruses can multiply. If an activity, such as eating toxic foods, has previously exposed the body to infection and inflammation, there is a benefit in retaining a memory of that condition so that you are better prepared to deal with danger. Engaged in the same activity. The shorter response time allows the body to beat the infection faster and with less effort. The problem, of course, arises when this mechanism gets out of hand and can cause disease on its own.”

It is a major advance in understanding how the human mind and body affect each other, and more specifically a better understanding of so-called psychosomatic diseases, such as irritable bowel syndrome, and other autoimmune diseases or allergies.

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