Hormone replacement therapy may increase the risk of depression Health City Berlin


Systemic hormone replacement therapy in postmenopausal women may increase the risk of depression. Especially in patients up to the age of fifty. This is what a Danish study showed.

Systemic hormone replacement therapy may be associated with an increased risk of depression before and during menopause. This was shown by a study published in the specialized journal JAMA Open Network. The risk is especially high in the first few years after starting treatment.

during the menopause Estrogen and progesterone levels decrease. 60 to 70 percent of women suffer from it menopause symptoms Like mood swings and hot flashes. This is to prevent the administration of the hormone.

Researchers evaluated prescriptions for hormone preparations

The nationwide study included all women in Denmark aged 45 years between January 1, 1995 and December 31, 2017. They had not had their ovaries removed, and they did not have breast or reproductive cancer. They were observed until December 31, 2018.

Researchers from Bispebjerg and Frederiksberg Hospitals in Fredericksburg evaluated prescriptions for different types of hormone replacement therapy that were filled between 1995 and 2017. The method of administration was divided into systemic (oral or transdermal) and local (intravaginal or intrauterine).

Hormone replacement therapy can increase the risk of depression

The results showed that from 45 years to a mean age of 56 years, 189,821 women were receiving systemic or local hormone replacement therapy (23 percent) and 13,069 women were diagnosed with depression (1.6 percent).

Systemic hormone replacement therapy was started primarily before age 50 and was associated with an increased risk of developing depression later on, especially in women aged 45–50 years. In addition, the risks increased particularly in the year after starting treatment with both estrogen alone and estrogen plus progestin.

Local hormonal therapy reduced risk of depression from age 54

Locally administered hormone replacement therapy was not associated with a risk of depression in women under 45 years of age. It was even associated with a lower risk of depression when it started after age 54.


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